Autologous CD34+ Cell Therapy for Ischemic Tissue Repair
نویسندگان
چکیده
منابع مشابه
Intramyocardial, autologous CD34+ cell therapy for refractory angina.
RATIONALE A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function. OBJECTIVE Evaluate the safety and bioactivity of intramyocardial injections of autologous CD34+ cells in patients with refractory angina who have exhausted ...
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BACKGROUND/OBJECTIVES A large number of patients with coronary artery disease experience angina that is not suitable for revascularization and is refractory to conventional medical therapy. Laboratory and preclinical studies have provided evidence for the safety and potential efficacy of autologous CD34+ stem cell therapies as treatment for angina. Clinical studies investigating intramyocardial...
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Despite the progress in our understanding of genes essential for stem cell regulation and development, little is known about the factors secreted by stem cells and their effect on tissue regeneration. In particular, the factors secreted by human CD34+ cells remain to be elucidated. We have approached this challenge by performing a cytokine/growth factor microarray analysis of secreted soluble f...
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Articular cartilage forms the articulating surface of synovial joints. Along with the synovial fluid it facilitates near frictionless movement in healthy joints. Injuries to articular cartilage in the knee are frequent and can lead to severe osteoarthritis, which is expected to affect 25% of the adult population by 2030. Hyaline cartilage does not regenerate spontaneously when injured and the c...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2019
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-19-0240